Cognomen Mittelholzer (Mittelholzer 
) , worldwide, is a rare surname. The family name Mittelholzer is characteristic of Antigua and Barbuda, where it is quite a common surname, Switzerland, where it is quite a rare surname, and Guyana, where it is a rare surname. Measured by absolute frequency, it is commonest in Switzerland, the United States, and Antigua and Barbuda. Very seldom, Mittelholzer is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Mittelholzer | Antigua and Barbuda, Spain, Canada, Switzerland, United States |
| anton josef mittelholzer (1758-1827), CH (b. 1758) |
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walter mittelholzer Swiss aviation pioneer, CH (b. 1894) |
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| johann baptist mittelholzer (1883-1970), CH (b. 1883) |
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| edgar mittelholzer Guyanese writer, GY (b. 1909) |
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| leo mittelholzer Swiss politician (1923-2013), CH (b. 1923) |
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thomas mittelholzer CH (b. 1991) |
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| thomas mittelholzer Ph.D. ETH Zürich 1987 |
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| roman mittelholzer CH (b. 1992) |
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Mr, Fredi, Orfea, Marisa, Martin, Mervyn, Robert, Denise, George, Thomas, Heinz, Esther, Hannah, Herman, Iolzbau, Walter, Melissa, Michael, Michele, Allyson, Adeline, Ernest, Ellen, Norma, Linda, Ms, Bob, Leo, Mary, Alex, Andi, Anne, Rose, Rojo, Rico, Gaby, John, Megan, Sarah, Simon, Bruce, Kerry, Peter, Petal, David, Grace, Brianne, and Deborah