Family name Ephrem (Ephrem 
, Ефрем 
) , in all the world, is a common last name. The surname Ephrem is habitual in Ethiopia, where it is quite a common surname, Lebanon, where it is quite a rare surname, and Bulgaria. In absolute terms, it most frequently occurs in Ethiopia, Lebanon, and Tanzania. Also, Ephrem is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Ephrem | Ivory Coast, India, Rwanda, Ethiopia, Democratic Republic of the Congo |
| Ефрем | Kazakhstan, Russia, Bulgaria, Belarus, Armenia |
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sebhat ephrem Eritrean politician, ER (b. 1951) |
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mussie ephrem Swedish politician, SE (b. 1971) |
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| mathieu ephrem French comics artist, FR (b. 1976) |
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| elissa ephrem researcher |
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| menassie ephrem Ph.D. Arizona State University 2003 |
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| georges ephrem researcher (ORCID 0000-0002-3995-1140) |
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| georges ephrem professor of clinical medicine |
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| mérovée ephrem French figure skater, FR (b. 1990) |
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