Cognomen Ekwueme (Ekwueme 
) , across the world, is quite a common family name. The cognomen Ekwueme is characteristic of Nigeria, where it is quite a rare surname, Niger, where it is a rare surname, and Ireland. In absolute terms, it is the most numerous in Nigeria, Niger, and the United States. Likewise, Ekwueme is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Ekwueme | Niger, Sweden, Nigeria, United States, United Kingdom |
| lazarus ekwueme Nigerian musician, NG (b. 1936) |
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| samuel chijioke ekwueme Nigerian Politician, NG (b. 1965) |
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| emmanuel ekwueme Nigerian footballer, NG (b. 1979) |
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| chinazom n ekwueme researcher (ORCID 0000-0003-2617-2620) |
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| daberechi chikezie ekwueme researcher (ORCID 0000-0002-0814-1436) |
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| destiny ekwueme actress |
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| donatus u ekwueme researcher |
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| paschal ekwueme Nigerian footballer, NG (b. 1982) |
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